- Title
- Biomarker of early glomerular injury in pre-eclampsia
- Creator
- Kandasamy, Yogavijayan; Watson, David; Rudd, Donna
- Relation
- Hypertension in Pregnancy Vol. 34, Issue 4, p. 391-399
- Publisher Link
- http://dx.doi.org/10.3109/10641955.2015.1065883
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2015
- Description
- Objectives: Nephrin is an integral part of podocytes that together with endothelial cells and the basement form the glomerular filtration barrier. Placental ischemia triggers a cascade of events that ultimately result in endothelial malfunction, hypertension, podocytopathy and fetal compromise. Methods: We review the literature to determine if urine nephrin measurements could serve as a useful biomarker to detect early podocyte injury in pre-eclampsia. Results: Our search identifies eight studies published to date. The findings of these studies demonstrate that urine nephrin excretion plays a critical role in the pathogenesis of proteinuria during pre-eclampsia and that this is a good indicator of glomerular injury. Conclusion: There is thus an urgent need for a large multi-centre clinical study using standardized recruitment criteria to determine the full potential of this biomarker in clinical practice.
- Subject
- nephrin; pre-eclampsia; podocytopathy; glomerular injury; hypertension
- Identifier
- http://hdl.handle.net/1959.13/1315028
- Identifier
- uon:22880
- Identifier
- ISSN:1064-1955
- Language
- eng
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